Xiaoni Ai
Associate Professor, Ph.D.
Young Elite Scientists Sponsorship Program (2020)
Email：aixn@bjmu.edu.cn
Address：38 Xueyuan Road, Haidian District, Peking University, Beijing, China, 100191
Education
● 2004-2008, College of Chemistry and Molecular Sciences, Wuhan University, B.S. (Advisor: Professor Weihua Huang)
● 2008-2013, Department of Chemistry, Tsinghua University, Ph.D. (Advisor: Professor Guoan Luo)
● 2011-2013, Biomedical Engineering, Georgia Institute of Technology, Joint Ph.D. (Advisor: Professor Hang Lu)
Professional Experience
● 2013-2021, Assistant Professor, School of Pharmaceutical Sciences, Peking University
● 2021-present, Associate Professor, School of Pharmaceutical Sciences, Peking University
Academic Services
● The member of Organoid and Organ-on-Chip Committee in Chinese Society of Biomedical Engineering
● The member of Pharmaceutical Analysis Committee in China Medicinal Biotechnology Association
● The member of Committee for the New Drug Development by Integrated Chinese and Western Medicines in Chinese Research Hospital Association
Research Areas
● Organ-on-Chip and Organoid-on-Chip
● Pharmaceutical Analysis
● Effective Components and Mechanism of Natural Products
Research Interests
Based on microfluidic chip, stem cell, and tissue engineering, we are developing organ-on-chip and organoid-on-chip models for drug development and precision medicine. The innovative models offer biomimetic microphysiological and micropathophysiological system for disease modeling and mechanisms studies. I have applied the models for elucidating the effective components and mechanism of natural product. The research area involves the interdisciplinary of pharmaceutical sciences, biomedical engineering, biology, and medicine.
Grants and fundings
● Natural Science Foundation of China (82174086) 2022.1-2025.12
● Beijing Natural Science Foundation (7222273) 2022.1-2024.12
● Young Elite Scientists Sponsorship Program (2020-QNRC2-08) 2020.1-2022.12
● Drug Innovation Major Project (2018ZX09711001-008-003) 2018.1-2022.12
● Natural Science Foundation of China (81402890) 2015.1-2017.12
Selected Publications
1. Xiaoni Ai, Yang Wu, Wenbo Lu, Xinran Zhang, Lin Zhao, Pengfei Tu*, Kewei Wang*, Yong Jiang*. A Precise Microfluidic Assay in Single-Cell Profile for Screening of Transient Receptor Potential Channel Modulators. Advanced Science, 2020, 7(11): 2000111.
2. Rong-Rong Xiao, Bolin Jing, Lei Yan, Jiajia Li, Pengfei Tu*, Xiaoni Ai*. Constant-rate perfused array chip for high-throughput screening of drug permeability through brain endothelium. Lab on a Chip, 2022, 22(23): 4481-4492
3. Xiaoni Ai, Lin Zhao, Yingyuan Lu, Yu Hou, Tian Lv, Pengfei Tu*, Xiaoyu Guo*. Integrated Array Chip for High-Throughput Screening of Species Differences in Metabolism. Analytical Chemistry, 2020, 92(17):11696-11704.
4. Xiaoni Ai, Wenbo Lu, Kewu Zeng, Chun Li, Yong Jiang*, Pengfei Tu*. Microfluidic Coculture Device for Monitoring of Inflammation-Induced Myocardial Injury Dynamics. Analytical Chemistry, 2018, 90(7): 4485-4494.
5. Yu Hou#, Xiaoni Ai#, Zhao Lin, Zhao Gao, Yujiang Wang, Yingyuan Lu, Pengfei Tu, Yong Jiang*. An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening. Lab on a Chip, 2020, 20(14):2482-2494. (Co-first authors)
6. Xiaoni Ai, Weipeng Zhuo, Qionglin Liang*, Patrick T McGrath*, Hang Lu*. A high-throughput device for size based separation of C. elegans developmental stages. Lab on a Chip, 2014, 14: 1746-1752.
7. Xiaoni Ai, Qionglin Liang, Minna Luo, Kai Zhang, Junmin Pan*, Guoan Luo*. Controlling gas/liquid exchange using microfluidics for real-time monitoring of flagellar length in living Chlamydomonas at the single-cell level. Lab on a Chip, 2012, 12: 4516-4522.
8. Rong-Rong Xiao, Lei Jin, Nan Xie, Piaopiao Luo, Wenjie Gao, Pengfei Tu, Xiaoni Ai*. Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation. Frontiers in Pharmacology, 2022, 13: 1032975.
9. Yancheng Cui, Rongrong Xiao, Yushi Zhou, Jianchuang Liu, Yi Wang, Xiaodong Yang, Zhanlong Shen, Bin Liang, Kai Shen, Yi Li, Geng Xiong, Yingjiang Ye, Xiaoni Ai*. Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy. Bio-Design and Manufacturing, 2022, 674–686.
10. Rong-Rong Xiao, Tian Lv, Xia Tu, Peiwen Li, Tiantian Wang, Haiheng Dong, Pengfei Tu, Xiaoni Ai*. An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. Biotechnology and Bioengineering, 2021, 118(12):4687-4698.
