Shi Yujie

Lecturer of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University

Research Areas

Drug Delivery System

Biological imaging

Education & Positions

China Pharmaceutical University, B.S., 1995-1999.

Peking University, M.S., 2002-2005.

PekingUniversity, Ph.D., 2013-2016.

Peking University,Teaching assistant of Pharmaceutical Analysis,Aug.2005- Aug.2007.

Peking University, Lecturer of Pharmaceutical Analysis, 2007-.

Research Interests

She is mainly engaged in research and development of the novel nano-drug delivery system including of using nano-technology to improve the absorption of poor water soluble drugs, studying the transport route and disciplines and elucidating the related mechanism of the novel DDS with different methods from subcellular, cellular level and the overall animal level. Fluorescence probe tracer imaging method, Raman imaging, transmission election microscopy and Multispectral Optoacoustic Tomography (MSOT) were used to conduct in vitro and in vivo evaluations of novel nano-drug delivery system. She has accumulated experience in drug delivery and biological imaging.

Grants and fundings

The mechanism study of single-walled carbon nanohorns enhancing membrane penetrating and oral absorption of poorly soluble drugs (The National Natural Science Foundation project youth's project, 81603041).

Publications

1. He, B.; Shi, Y. J.; Liang, Y. Q.; Yang, A. P., Fan, Z. P.; Yuan, L.; Zou, X.; Chang, X.; Zhang, H.; Wang, X. Q.; Dai, W. B.; Wang, Y. G.; Zhang. Q.*Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages.Nature Communications. 2018, 9(1), 2393.

2. Shi, Y. J.; Shi, Z. J.; Li, S. X.; Zhang, Y.; He, B.; Peng, D.; Tian, J.; Zhao, M.*; Wang, X. Q.*; Zhang. Q. The interactions of single-wall carbon nanohorns with polar epithelium. International Journal of Nanomedicine. 2017, 12, 4177-4194.

3. Li, S. X.; Wang, K. K.; Shi, Y. J.; Cui, Y. N.; Chen, B. L.; He, B.; Dai, W. B.; Zhang, H.; Wang, X. Q.; Zhong, C. L.; Wu, H. N.; Yang, Q. Y.; Zhang. Q.*Novel Biological Functions of ZIF-NP as a Delivery Vehicle: High Pulmonary Accumulation, Favorable Biocompatibility and Improved Therapeutic Outcome. Advanced Functional Materials. 2016, 26(16), 2715.

4. Wang, D.; Fu, J. J.; Shi, Y. J.; Peng, D.; Yuan, L.; He, B.; Dai, W. B.; Zhang, H.; Wang, X. Q.; Tian, J.; Zhang. Q.*The modulation of tumor vessel permeability by thalidomide and its impacts on different types of targeted drug delivery systems in a sarcoma mouse model. Journal of Controlled Release. 2016, 238:186-196.

5. Wang, X. Q.; Li, S. X.; Shi, Y. J.; Chuan, X. X.; Li, J.; Zhong, T.; Zhang, H.; Dai, W. B.; He, B.; Zhang Q.*  The Development of Site-specific Drug Delivery Nanocarriers Based on Receptor Mediation. Journal of Controlled Release. 2014, 193, 139–153.