Xue Qiao, Ph D., Professor

School of Pharmaceutical Sciences, Peking University

E-mail: qiaoxue@bjmu.edu.cn

We are recruiting research assistants, postdoctoral researchers and doctoral candidates. Welcome to join us!

Education and Professional Career

2003/09–2007/07, B.Sc. in Pharmaceutical Sciences, Peking University.

2007/09–2012/07, M.Sc. in Pharmacognosy, Peking University.

2009/09–2012/07, Ph.D. in Pharmacognosy, Peking University.

2012/08-2021/12, Lecturer, Associate Professor, School of Pharmaceutical Sciences, Peking University.

2016/10-2018/04, Visiting Scientist (Post-Doc), John Innes Centre, UK.

2022/01-present, Professor, School of Pharmaceutical Sciences, Peking University.

Research Interests

Biosynthesis of natural products in Traditional Chinese medicines.

New chemical analysis methods for metabolomics and for Chinese herbal medicines.

Selected Publications

1. Mingju Yao#, Haotian Wang#, Zilong Wang, Chenglin Song, Xiaolin Sa, Wei Du, Min Ye, Xue Qiao*. Construct phenylethanoid glycosides harnessing biosynthetic networks, protein engineering and one-pot multienzyme cascades. Angew. Chem. Int. Ed. 2024, e202402546.

2. Linlin Wang#, Zhihui Jiang#, Jiahe Zhang#, Kuan Chen, Meng Zhang, Zilong Wang, Binju Wang*, Min Ye*, Xue Qiao*. Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus. Nature Commun. 2023, 14, 5969.

3. Hao-Tian Wang#, Zi-Long Wang#, Kuan Chen, Ming-Ju Yao, Meng Zhang, Rong-Shen Wang, Jia-He Zhang, Hans Ågren, Fu-Dong Li, Junhao Li, Xue Qiao*, Min Ye*. Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants. Nature Commun., 2023, 14, 6658.

4. Kuan Chen#, Meng Zhang#, Baihan Gao#, Aobulikasimu Hasan, Junhao Li, Yang’oujie Bao, Jingjing Fan, Rong Yu, Yang Yi, Hans Agren, Zilong Wang, Haiyang Liu, Min Ye*, Xue Qiao*. Characterization and protein engineering of glycosyltransferases for the biosynthesis of diverse hepatoprotective cycloartane-type saponins in Astragalus membranaceus. Plant Biotechnol. J. 2023, 21, 698–710.

5. Meng Zhang, Yang Yi, Baihan Gao, Hui-Fei Su, Yang-Oujie Bao, Xiao-Meng Shi, Hai-Dong Wang, Fu-Dong Li, Min Ye*, Xue Qiao*. Functional characterization and protein engineering of a triterpene 3-/6-/2′-O-glycosyltransferase reveal a conserved residue critical for the regiospecificity. Angew. Chem. Int. Ed. 2022, 61(8), e202113587.

6. Kuan Chen, Meng Zhang, Min Ye*, Xue Qiao*. Site-directed mutagenesis and substrate compatibility to reveal the structure-function relationships of plant oxidosqualene cyclases. Nat. Prod. Rep. 2021, 38, 2261-2275.

7. Zi-Long Wang#, Hao-Meng Gao#, Shuang Wang, Meng Zhang, Kuan Chen, Ya-Qun Zhang, Hai-Dong Wang, Bo-Yun Han, Lu-Lu Xu, Tian-Qiao Song, Cai-Hong Yun, Xue Qiao*, Min Ye*. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc. Natl. Acad. Sci. U. S. A. 2020, 117(48), 30816-30823

8. Meng Zhang#, Fu-Dong Li#, Kai Li#, Zi-Long Wang, Yu-Xi Wang, Jun-Bin He, Hui-Fei Su, Zhong-Yi Zhang, Chang-Biao Chi, Xiao-Meng Shi, Cai-Hong Yun, Zhi-Yong Zhang, Zhen-Ming Liu, Liang-Ren Zhang, Dong-Hui Yang, Ming Ma*, Xue Qiao*, Min Ye*. Functional characterization and structural basis of an efficient di-C-glycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc. 2020, 142, 3506-3512.

9. Jun-Bin He#, Peng Zhao#, Zhi-Min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-Hong Yun*, Xue Qiao*, Min Ye*. Molecular characterization and structural basis of a promiscuous C-glycosyltransferase from Trollius chinensis. Angew. Chem. Int. Ed. 2019, 58, 11513-11520.