Current Location: Professor

Zhang Liqin


Zhang Liqin

Assistant Professor and Principle Investor

Phone+86-010-82805508; E-mail:

AddressSPS 323, 38 Xueyuan Rd, Haidian District, Beijing 100191, China


Education/Working Experience

● 2005-2011    Peking University School of Pharmaceutical Sciences           B.S./M.S.

● 2011-2016    University of Florida Department of Chemistry and UF Health Cancer Center        PhD

● 2018-2019    Stanford University Medical School                                       Postdoctoral Researcher

● 2020-2021    Thermo Fisher Scientific                                                         Scientist

● 2021-            Peking University School of Pharmaceutical Sciences           Assistant Professor                              


Research Interests

● Construction and application of  multivariant functional nucleic acid probes

● Bioanalytical strategies for regulation of physiological and pharmacological mechanism

● Design and development of functional nucleic acid modality

● Drug target discovery and drug development


Selected Publications

1. Liqin Zhang, Sai Wang, Zunyi Yang, Shuichi Hoshika, Sitao Xie, Jin Li, Xigao Chen, Shuo Wan, Long Li, Steven A Benner, Weihong Tan. An Aptamer‐Nanotrain Assembled from 6‐Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells, Angewandte Chemie International Edition, 2020, 132 (2), 673-678.

2. Jun Li, Yao-Yao Fan, Man Wang, Hui-Ling Duan, Jing Zhang, Fuquan Dang, Liqin Zhang*, Zhi-Qi Zhang*. A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-Ι RNA-Binding Small Molecules. Analytical Chemistry, 2020, 92(19), 13532-13538.

3. Lianhui Zhao, Xiaoyan Qi, Xiaochen Yan, Yunfei Huang, Xingguo Liang, Liqin Zhang*, Sai Wang*, Weihong Tan*. Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation. Journal of the American Chemical Society, 2019, 141 (44), 17493-17497. (*co-corresponding authored)

4. Liqin Zhang, Shuo Wan, Ying Jiang, Yanyue Wang, Ting Fu, Qiaoling Liu, Zhijuan Cao, Liping Qiu, and Weihong Tan. Molecular Elucidation of Disease Biomarkers at the Interface of Chemistry and Biology. Journal of the American Chemical Society, 2017, 139 (7), 2532–2540.

5. Shuo Wan#, Liqin Zhang#, Sai Wang, Sena Cansiz, Hui Zhang, Yuan Liu, Cheng Cui, Weihong Tan, DNA Nanoassembly on Exosome Membrane Surfaces for Enhanced Fluorescent Detection. Journal of the American Chemical Society, 2017, 139 (15), 5289-5292. (#co-fist authored)

6. Sai Wang#, Liqin Zhang#, Shuo Wan, Sena Cansiz, Yuan Liu, Ren Cai, Cheng-Yi Hong, I-Ting Teng, Muling Shi, Yuan Wu, Yiyang Dong, and Weihong Tan, Aptasensor with Expanded Nucleotide using DNA Nanotetrahedra for Electrochemical Detection of Cancerous Exosomes.  ACS Nano, 2017, 11 (4), 3943-394911. (#co-fist authored)

7. Liqin Zhang, Zunyi Yang,Thu Le Trinh, I-Ting Teng, Sai Wang, Kevin M Bradley, Shuichi Hoshika, Qunfeng Wu, Sena Cansiz, Diane J Rowold, Christopher McLendon, Myong-Sang Kim, Yuan Wu, Cheng Cui, Yuan Liu, Weijia Hou, Kimberly Stewart, Shuo Wan, Chen Liu, Steven A. Benner, Weihong Tan. Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution Give Aptamers against Glypican-3-Overexpressing Tumor Cells. Angewandte Chemie International Edition, 2016, 55(40), 12372-12375.

8. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Elizabeth Jimenez, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L Gerloff, Zhen Huang, Weihong Tan, Steven A Benner. Evolution of Functional Six-Nucleotide DNA. Journal of the American Chemical Society, 2015, 111 (4), 1449-1454.

9. Liqin Zhang, Guizhi Zhu, Lei Mei, Cuichen Wu, Liping Qiu, Cheng Cui, Yuan Liu, I-Ting Teng, and Weihong Tan. Self-Assembled DNA Immuno-Nanoflowers as Multivalent CpG Nanoagents. ACS Applied Materials & Interfaces, 2015, 7 (43), 24069-24074.

10. Liqin Zhang. Unnatural Nucleic Acids for Aptamer Selection. In Aptamers Selected by Cell-SELEX for Theranostics. Xiaohong Fang, Weihong Tan, Eds.; Springer Berlin Heidelberg, 2015, pp 35-65.

11. Sena Cansiz*, Liqin Zhang*, Cuichen Wu, Yuan Wu, I-Ting Teng, Weijia Hou, Yanyue Wang, Shuo Wan, Ren Cai, Chen Jin, Qiaoling Liu, Weihong Tan. DNA Aptamer Based Nanodrugs: Molecular Engineering for Efficiency. Chemistry–An Asian Journal, 2015, 10, 2084-2094. (*co-fist authored)

12. Li-Qin Zhang, Xiu-Wei Yang, You-Bo Zhang, Ya-Ya Zhai, Wei Xu, Bo Zhao, Dai-Lin Liu, Hong-Jian Yu. Biotransformation of Phlorizin by Human Intestinal Flora and Inhibition of Biotransformation Products on Tyrosinase Activity. Food Chemistry, 2012, 132(2), 936–942.

13. Li-Qin Zhang, Ying-Dong Huang, Xiu-Wei Yang. Intestinal Permeability of Liquiritin and Isoliquiritin in the Caco-2 cell Monolayer Model. Journal of Chinese Pharmaceutical Sciences, 2010, 19(6), 451-458. 


Our research group eagerly welcomes talents from all over the world to join us as graduate students or postdoctoral researchers. Please send your CV to