Li Xianchan
Assistant Professor and Principle Investor
Phone：+86-010-82805716; E-mail: xcli@hsc.pku.edu.cn
Address：SPS 323, 38 Xueyuan Rd, Haidian District, Beijing 100191, China
Education/Working Experience
● 2000-2004 Peking University, School of Pharmaceutical Sciences B.S.
● 2004-2009 Institute of Chemistry, Chinese Academy of Sciences PhD
● 2009-2013 Institute of Chemistry, Chinese Academy of Sciences Assistant Professor
● 2013-2015 Chalmers University of Technology Postdoc
● 2015-2018 University of Gothenburg Researcher
● 2018-2021 Minzu University of China PI, Professor
● 2021- Peking University PI, Assistant Professor
Research Interests
● Construction and application of electrochemical approaches for pharmaceutical analysis
● Bioanalytical strategies for regulation of neuro-physiological and pharmacological mechanism
● Drug target discovery and drug development
Selected Publications
1. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117. DOI: 10.1002/anie.202117596.
2. Yuying Liu,† Jinchang Du,† Mengying Wang, Jing Zhang, Chunlan Liu* and Xianchan Li*, Recent Progress in Quantitatively Monitoring Vesicular Neurotransmitter Release and Storage with Micro/Nanoelectrodes. Front. Chem. 2021, 8, 591311. (Invited)
3. Qingwei Yue,† Xianchan Li,† Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes, Angew. Chem. Int. Ed. 2020, 59, 11061– 11065. (Co-first authors)
4. Dalei Wang,† Xianchan Li,† Ying Jiang, Yanan Jiang, Wenjie Ma, Ping Yu, and Lanqun Mao*. Ischemic Postconditioning Recovers Cortex Ascorbic Acid during Ischemia/Reperfusion Monitored with an Online Electrochemical System. ACS Chem. Neurosci. 2019, 10, 2576-2583. (Co-first authors)
5. Amir S Mohammadi,† Xianchan Li†, Andrew G. Ewing*. Mass Spectrometry Imaging Suggests That Cisplatin Affects Exocytotic Release by Alteration of Cell Membrane Lipids. Anal. Chem. 2018, 90, 8509-8516. (Co-first authors)
6. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. On the Nanopore Opening at Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018,12, 3010-3019.
7. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.
8. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measurement of synaptic vesicles: from the chemical content to structure and activity using cellular electrochemistry and nanoscale molecular imaging. Nature Reviews Chemistry, 2017, 1, 0048.
9. Xianchan Li,† Johan Dunevall,† Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.
10. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. Cover：Angew. Chem. Int. Ed. 2016, 55, 9098.
11. Xianchan Li,† Soodabeh Majdi,† Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.
12. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal.Chem. 2012, 84, 9416-9421.
13. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal.Chem. 2012, 84, 5285-5291.
14. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.
Our research group eagerly welcomes talents from all over the world to join us as graduate students or postdoctoral researchers. Please send your CV to xcli@hsc.pku.edu.cn
