Current Location: Professor

Li Xianchan

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Li Xianchan

Assistant Professor and Principle Investor

Phone+86-010-82805716; E-mail: xcli@hsc.pku.edu.cn

AddressSPS 323, 38 Xueyuan Rd, Haidian District, Beijing 100191, China


Education/Working Experience

● 2000-2004    Peking University, School of Pharmaceutical Sciences            B.S.

● 2004-2009    Institute of Chemistry, Chinese Academy of Sciences         PhD

● 2009-2013 Institute of Chemistry, Chinese Academy of Sciences Assistant Professor

● 2013-2015  Chalmers University of Technology Postdoc

● 2015-2018  University of Gothenburg Researcher

● 2018-2021    Minzu University of China PI, Professor

● 2021-            Peking University           PI, Assistant Professor


Research Interests

● Construction and application of electrochemical approaches for pharmaceutical analysis

● Bioanalytical strategies for regulation of neuro-physiological and pharmacological mechanism

● Drug target discovery and drug development

Selected Publications


1. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117. DOI: 10.1002/anie.202117596.

2. Yuying Liu, Jinchang Du, Mengying Wang, Jing Zhang, Chunlan Liu* and Xianchan Li*, Recent Progress in Quantitatively Monitoring Vesicular Neurotransmitter Release and Storage with Micro/Nanoelectrodes. Front. Chem. 2021, 8, 591311. (Invited)

3. Qingwei Yue, Xianchan Li,Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ1 Protein in Vesicular Storage and Release of Catecholamine with Nano/MicroTip Electrodes, Angew. Chem. Int. Ed. 2020, 59, 11061– 11065. (Co-first authors)

4. Dalei Wang, Xianchan Li, Ying Jiang, Yanan Jiang, Wenjie Ma, Ping Yu, and Lanqun Mao*. Ischemic Postconditioning Recovers Cortex Ascorbic Acid during Ischemia/Reperfusion Monitored with an Online Electrochemical System. ACS Chem. Neurosci. 2019, 10, 2576-2583. (Co-first authors)

5. Amir S Mohammadi,Xianchan Li, Andrew G. Ewing*. Mass Spectrometry Imaging Suggests That Cisplatin Affects Exocytotic Release by Alteration of Cell Membrane Lipids. Anal. Chem. 2018, 90, 8509-8516. (Co-first authors)

6. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. On the Nanopore Opening at Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018,12, 3010-3019.

7. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.

8. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measurement of synaptic vesicles: from the chemical content to structure and activity using cellular electrochemistry and nanoscale molecular imaging. Nature Reviews Chemistry, 2017, 1, 0048.

9. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.

10. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. CoverAngew. Chem. Int. Ed. 2016, 55, 9098.

11. Xianchan Li, Soodabeh Majdi, Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.

12. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal.Chem. 2012, 84, 9416-9421.

13. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal.Chem. 2012, 84, 5285-5291.

14. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.


Our research group eagerly welcomes talents from all over the world to join us as graduate students or postdoctoral researchers. Please send your CV to lqzhang@hsc.pku.edu.cn