Dr. Xianchan Li
Assistant Professor and Principle Investor
Phone：+86-010-82805716; E-mail: xcli@pku.edu.cn
Address：SPS 323, 38 Xueyuan Rd, Haidian District, Beijing 100191, China
Education/Working Experience
● 2000-2004 Peking University, School of Pharmaceutical Sciences B.S.
● 2004-2009 Institute of Chemistry, Chinese Academy of Sciences PhD
● 2009-2013 Institute of Chemistry, Chinese Academy of Sciences Assistant Professor
● 2013-2015 Chalmers University of Technology Postdoc
● 2015-2018 University of Gothenburg Researcher
● 2018-2021 Minzu University of China PI, Professor
● 2021- Peking University PI, Assistant Professor (Tenure-Track)
Research Interests
● Construction and application of electrochemical approaches for pharmaceutical analysis
● Bioanalytical strategies for regulation of neuro-physiological and pharmacological mechanism
● Neural drug target discovery and drugdevelopment
Selected Publications
1. Yuhang Jiang§, Luyao Liu§, Meiping Xiong§, Weiyu Liu, Haixin Wang, Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Chao Yuan, Lanqun Mao*, Xianchan Li*, A Single-Vesicle Electroanalytical Approach Uncovers Deficits of Vesicular Acetylcholine in Alzheimer’s Disease, J. Am. Chem. Soc. 2026, 148, 15, 15848-15858.
2. Jinger Chen§, Yuying Liu§, Lijiao Cao, Junlan Zhou, Xiaoke Nan, Chuqi Li, Weiyu Liu, Meiping Xiong, Yuhang Jiang, Qianhe Dai, Chao Yuan, Xianchan Li*, Investigating the Effect of Oxaliplatin on Vesicular Dopamine Cargo and Release Dynamics in Brain with Single-Vesicle Electrochemistry, Anal. Chem. 2026, 98, 3307-3315.
3. Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Jinchang Du, Yifei Xue, Xianchan Li*, Lanqun Mao, Single-Vesicle Electrochemistry in Fresh Brain Slices Enables In Situ Quantification of Vesicular Monoamine, J. Am. Chem. Soc. 2025, 147, 149-160.
4. Lijiao Cao, Jing Zhang, Mo Li, Junlan Zhou, Yuying Liu, Chunlan Liu*, Xianchan Li*, Single-Vesicle Electrochemistry Reveals Polysaccharide from Glochidion eriocarpum Champ. Regulates Vesicular Storage and Exocytotic Release of Dopamine. Anal. Chem. 2024, 96, 15248-15256.
5. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117.
6. Qingwei Yue†, Xianchan Li†, Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes. Angew. Chem. Int. Ed. 2020, 59, 11061– 11065.
7. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. Nanopore Opening at Flat and Nanotip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018, 12, 3010-3019.
8. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.
9. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measuring synaptic vesicles using cellular electrochemistry and nanoscale molecular imaging. Nat. Rev. Chem. 2017, 1, 0048. DOI: 10.1038/s41570-017-0048
10. Xianchan Li†, Johan Dunevall†, Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.
11. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044.
12. Xianchan Li†, Soodabeh Majdi†, Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.
Our research group eagerly welcomes talents from all over the world to join us as graduate students or postdoctoral researchers. Please send your CV to xcli@pku.edu.cn.
