Dr. Xianchan Li
Assistant Professor and Principle Investor
Phone：+86-010-82805716; E-mail: xcli@pku.edu.cn
Address：SPS 323, 38 Xueyuan Rd, Haidian District, Beijing 100191, China
Education/Working Experience
● 2000-2004 Peking University, School of Pharmaceutical Sciences B.S.
● 2004-2009 Institute of Chemistry, Chinese Academy of Sciences PhD
● 2009-2013 Institute of Chemistry, Chinese Academy of Sciences Assistant Professor
● 2013-2015 Chalmers University of Technology Postdoc
● 2015-2018 University of Gothenburg Researcher
● 2018-2021 Minzu University of China PI, Professor
● 2021- Peking University PI, Assistant Professor
Research Interests
● Construction and application of electrochemical approaches for pharmaceutical analysis
● Bioanalytical strategies for regulation of neuro-physiological and pharmacological mechanism
● Neural drug target discovery and drug development
Selected Publications
1. Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Jinchang Du, Yifei Xue, Xianchan Li*, Lanqun Mao, Single-Vesicle Electrochemistry in Fresh Brain Slices Enables In Situ Quantification of Vesicular Monoamine, J. Am. Chem. Soc. 2025, 147, 149-160.
2. Lijiao Cao, Jing Zhang, Mo Li, Junlan Zhou, Yuying Liu, Chunlan Liu*, Xianchan Li*, Single-Vesicle Electrochemistry Reveals Polysaccharide from Glochidion eriocarpum Champ. Regulates Vesicular Storage and Exocytotic Release of Dopamine. Anal. Chem. 2024, 96, 15248-15256.
3. Xiaoke Nan, Mengying Wang, Jinchang Du, Yuying Liu, Lijiao Cao, Junlan Zhou, Luyao Liu, Xianchan Li*. Single vesicle chemistry reveals partial release happens at the mechanical stress-induced exocytosis. Talanta 2024, 271, 125637.
4. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117.
5. Qingwei Yue†, Xianchan Li†), Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes. Angew. Chem. Int. Ed. 2020, 59, 11061– 11065.
6. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. Nanopore Opening at Flat and Nanotip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018, 12, 3010-3019.
7. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.
8. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measuring synaptic vesicles using cellular electrochemistry and nanoscale molecular imaging. Nat. Rev. Chem. 2017, 1, 0048. DOI: 10.1038/s41570-017-0048
9. Xianchan Li†, Johan Dunevall†,(Co-first authors) Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.
10. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. (Back cover)
11. Xianchan Li†, Soodabeh Majdi†,(Co-first authors) Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.
12. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal. Chem. 2012, 84, 9416-9421.
13. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal. Chem. 2012, 84, 5285-5291.
14. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.
Our research group eagerly welcomes talents from all over the world to join us as graduate students or postdoctoral researchers. Please send your CV to xcli@pku.edu.cn.
