您目前的位置: 首页» 师资队伍» 副教授

艾晓妮

20de700d0e7f49499f8b64c033cd830a.jpg

艾晓妮,博士,副研究员,研究生导师

入选中华中医药学会青年人才托举工程(2020)

Email:aixn@bjmu.edu.cn

地址:北京市海淀区学院路38号北京大学医学部卫生楼208,邮编:100191


教育经历

2004.09-2008.06,武汉大学,学士

2008.09—2013.07,清华大学,博士

2011.08—2013.02,美国佐治亚理工学院,联合培养博士


工作履历

2013.07-2021.08,北京大学药学院,讲师

2021.08-至今,北京大学药学院,副研究员


学术兼职

1. 国家工信部“专精特新”评审专家

2. 中国医药生物技术协会药物分析分会委员

3. 中国生物医学工程学会类器官与器官芯片分会委员

4. 中国中药协会中药产品开发与培育委员会常务委员

5. 中国研究型医院学会中西医结合新药创制专业委员会委员


研究领域

以微流控芯片、干细胞和组织工程为基础,发展器官芯片和类器官新模型,服务于国家新药创制、中药现代化和精准医疗的研究与转化。研究领域涉及药学、生物学、医学、工程学的学科交叉。以第一作者或通讯作者在Advanced Science、Analytical Chemistry、Lab Chip等学术期刊上发表了研究论文20余篇。主持国家级科研项目2项,北京市自然基金科学基金面上项目1项;作为科研骨干参与科技部重大新药创制、国自然重点项目等4项。部分研究成果已在制药企业和临床医院应用,申请国家发明专利3项,已授权2项。


研究方向

1. 器官芯片和类器官新方法

2. 天然药物活性成分发现及作用机制研究


代表性论文

1. Xiaoni Ai, Yang Wu, Wenbo Lu, Xinran Zhang, Lin Zhao, Pengfei Tu*, Kewei Wang*, Yong Jiang*. A Precise Microfluidic Assay in Single-Cell Profile for Screening of Transient Receptor Potential Channel Modulators. Advanced Science, 2020, 7(11): 2000111.

2. Rong-Rong Xiao, Bolin Jing, Lei Yan, Jiajia Li, Pengfei Tu*, Xiaoni Ai*. Constant-rate perfused array chip for high-throughput screening of drug permeability through brain endothelium. Lab on a Chip, 2022, 22(23): 4481-4492

3. Xiaoni Ai, Lin Zhao, Yingyuan Lu, Yu Hou, Tian Lv, Pengfei Tu*, Xiaoyu Guo*. Integrated Array Chip for High-Throughput Screening of Species Differences in Metabolism. Analytical Chemistry, 2020, 92(17):11696-11704.

4. Xiaoni Ai, Wenbo Lu, Kewu Zeng, Chun Li, Yong Jiang*, Pengfei Tu*. Microfluidic Coculture Device for Monitoring of Inflammation-Induced Myocardial Injury Dynamics. Analytical Chemistry, 2018, 90(7): 4485-4494.

5. Yu Hou#, Xiaoni Ai#, Zhao Lin, Zhao Gao, Yujiang Wang, Yingyuan Lu, Pengfei Tu, Yong Jiang*. An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening. Lab on a Chip, 2020, 20(14):2482-2494. (Co-first authors)

6. Xiaoni Ai, Weipeng Zhuo, Qionglin Liang*, Patrick T McGrath*, Hang Lu*. A high-throughput device for size based separation of C. elegans developmental stages. Lab on a Chip, 2014, 14: 1746-1752.

7. Xiaoni Ai, Qionglin Liang, Minna Luo, Kai Zhang, Junmin Pan*, Guoan Luo*. Controlling gas/liquid exchange using microfluidics for real-time monitoring of flagellar length in living Chlamydomonas at the single-cell level. Lab on a Chip, 2012, 12: 4516-4522.

8. Rong-Rong Xiao, Lei Jin, Nan Xie, Piaopiao Luo, Wenjie Gao, Pengfei Tu, Xiaoni Ai*. Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation. Frontiers in Pharmacology, 2022, 13: 1032975.

9. Yancheng Cui, Rongrong Xiao, Yushi Zhou, Jianchuang Liu, Yi Wang, Xiaodong Yang, Zhanlong Shen, Bin Liang, Kai Shen, Yi Li, Geng Xiong, Yingjiang Ye, Xiaoni Ai*. Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy. Bio-Design and Manufacturing, 2022, 674–686.

10. Rong-Rong Xiao, Tian Lv, Xia Tu, Peiwen Li, Tiantian Wang, Haiheng Dong, Pengfei Tu, Xiaoni Ai*. An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. Biotechnology and Bioengineering, 2021, 118(12):4687-4698.