艾晓妮，博士，副研究员，研究生导师
入选中华中医药学会青年人才托举工程（2020）
Email：aixn@bjmu.edu.cn
地址：北京市海淀区学院路38号北京大学医学部卫生楼208，邮编：100191
教育经历
2004.09－2008.06，武汉大学，学士
2008.09—2013.07，清华大学，博士
2011.08—2013.02，美国佐治亚理工学院，联合培养博士
工作履历
2013.07－2021.08，北京大学药学院，讲师
2021.08－至今，北京大学药学院，副研究员
学术兼职
1. 国家工信部“专精特新”评审专家
2. 中国医药生物技术协会药物分析分会委员
3. 中国生物医学工程学会类器官与器官芯片分会委员
4. 中国中药协会中药产品开发与培育委员会常务委员
5. 中国研究型医院学会中西医结合新药创制专业委员会委员
研究领域
以微流控芯片、干细胞和组织工程为基础，发展器官芯片和类器官新模型，服务于国家新药创制、中药现代化和精准医疗的研究与转化。研究领域涉及药学、生物学、医学、工程学的学科交叉。以第一作者或通讯作者在Advanced Science、Analytical Chemistry、Lab Chip等学术期刊上发表了研究论文20余篇。主持国家级科研项目2项，北京市自然基金科学基金面上项目1项；作为科研骨干参与科技部重大新药创制、国自然重点项目等4项。部分研究成果已在制药企业和临床医院应用，申请国家发明专利3项，已授权2项。
研究方向
1. 器官芯片和类器官新方法
2. 天然药物活性成分发现及作用机制研究
代表性论文
1. Xiaoni Ai, Yang Wu, Wenbo Lu, Xinran Zhang, Lin Zhao, Pengfei Tu*, Kewei Wang*, Yong Jiang*. A Precise Microfluidic Assay in Single-Cell Profile for Screening of Transient Receptor Potential Channel Modulators. Advanced Science, 2020, 7(11): 2000111.
2. Rong-Rong Xiao, Bolin Jing, Lei Yan, Jiajia Li, Pengfei Tu*, Xiaoni Ai*. Constant-rate perfused array chip for high-throughput screening of drug permeability through brain endothelium. Lab on a Chip, 2022, 22(23): 4481-4492
3. Xiaoni Ai, Lin Zhao, Yingyuan Lu, Yu Hou, Tian Lv, Pengfei Tu*, Xiaoyu Guo*. Integrated Array Chip for High-Throughput Screening of Species Differences in Metabolism. Analytical Chemistry, 2020, 92(17):11696-11704.
4. Xiaoni Ai, Wenbo Lu, Kewu Zeng, Chun Li, Yong Jiang*, Pengfei Tu*. Microfluidic Coculture Device for Monitoring of Inflammation-Induced Myocardial Injury Dynamics. Analytical Chemistry, 2018, 90(7): 4485-4494.
5. Yu Hou#, Xiaoni Ai#, Zhao Lin, Zhao Gao, Yujiang Wang, Yingyuan Lu, Pengfei Tu, Yong Jiang*. An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening. Lab on a Chip, 2020, 20(14):2482-2494. (Co-first authors)
6. Xiaoni Ai, Weipeng Zhuo, Qionglin Liang*, Patrick T McGrath*, Hang Lu*. A high-throughput device for size based separation of C. elegans developmental stages. Lab on a Chip, 2014, 14: 1746-1752.
7. Xiaoni Ai, Qionglin Liang, Minna Luo, Kai Zhang, Junmin Pan*, Guoan Luo*. Controlling gas/liquid exchange using microfluidics for real-time monitoring of flagellar length in living Chlamydomonas at the single-cell level. Lab on a Chip, 2012, 12: 4516-4522.
8. Rong-Rong Xiao, Lei Jin, Nan Xie, Piaopiao Luo, Wenjie Gao, Pengfei Tu, Xiaoni Ai*. Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation. Frontiers in Pharmacology, 2022, 13: 1032975.
9. Yancheng Cui, Rongrong Xiao, Yushi Zhou, Jianchuang Liu, Yi Wang, Xiaodong Yang, Zhanlong Shen, Bin Liang, Kai Shen, Yi Li, Geng Xiong, Yingjiang Ye, Xiaoni Ai*. Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy. Bio-Design and Manufacturing, 2022, 674–686.
10. Rong-Rong Xiao, Tian Lv, Xia Tu, Peiwen Li, Tiantian Wang, Haiheng Dong, Pengfei Tu, Xiaoni Ai*. An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. Biotechnology and Bioengineering, 2021, 118(12):4687-4698.
