李鲜婵
特聘研究员 课题组长 博士生导师
国家海外高层次人才计划“青年项目”获得者（2019）
电话：+86-010-82805716; E-mail: xcli@hsc.pku.edu.cn
地址：北京市海淀区学院路38号北京大学医学部药学楼
个人简历
● 2000-2004 北京大学药学院 学士
● 2004-2009 中国科学院大学研究所 博士
● 2009-2013 中国科学院化学研究所 助理研究员
● 2013-2015 瑞典查尔姆斯理工大学 博士后
● 2015-2018 瑞典哥德堡大学 研究员
● 2019-2021 中央民族大学 教授、课题组长、博士生导师
● 2021- 北京大学药学院 研究员、课题组长、博士生导师
研究方向
● 微纳电化学传感策略和药物分析应用
● 神经化学信号转导的分析与生理药理调控
● 生物分析策略与药物开发
● 神经系统疾病分子机制、药物新靶点发现及药物干预机制研究
代表性论文
1. Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Jinchang Du, Yifei Xue, Xianchan Li*, Lanqun Mao, Single-Vesicle Electrochemistry in Fresh Brain Slices Enables In Situ Quantification of Vesicular Monoamine, J. Am. Chem. Soc. 2025, 147, 149-160.
2. Lijiao Cao, Jing Zhang, Mo Li, Junlan Zhou, Yuying Liu, Chunlan Liu*, Xianchan Li*, Single-Vesicle Electrochemistry Reveals Polysaccharide from Glochidion eriocarpum Champ. Regulates Vesicular Storage and Exocytotic Release of Dopamine. Anal. Chem. 2024, 96, 15248-15256.
3. Xiaoke Nan, Mengying Wang, Jinchang Du, Yuying Liu, Lijiao Cao, Junlan Zhou, Luyao Liu, Xianchan Li*. Single vesicle chemistry reveals partial release happens at the mechanical stress-induced exocytosis. Talanta 2024, 271, 125637.
4. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117.
5. Qingwei Yue†, Xianchan Li†), Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes. Angew. Chem. Int. Ed. 2020, 59, 11061– 11065.
6. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. Nanopore Opening at Flat and Nanotip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018, 12, 3010-3019.
7. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.
8. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measuring synaptic vesicles using cellular electrochemistry and nanoscale molecular imaging. Nat. Rev. Chem. 2017, 1, 0048. DOI: 10.1038/s41570-017-0048
9. Xianchan Li†, Johan Dunevall†,(Co-first authors) Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.
10. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. (Back cover)
11. Xianchan Li†, Soodabeh Majdi†,(Co-first authors) Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.
12. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal. Chem. 2012, 84, 9416-9421.
13. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal. Chem. 2012, 84, 5285-5291.
14. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.
本课题组常年招收硕士和博士研究生，并面向全球诚聘博士后研究人员和研究助理，有意者请将个人简历发至xcli@pku.edu.cn
