李鲜婵
研究员 课题组长 博士生导师
国家海外高层次人才计划青年项目获得者
电话：+86-010-82805716; E-mail: xcli@pku.edu.cn
地址：北京市海淀区学院路38号北京大学医学部科技楼北楼1601
个人简历
● 2000-2004 北京大学药学院 学士
● 2004-2009 中国科学院大学研究所 博士
● 2009-2013 中国科学院化学研究所 助理研究员
● 2013-2015 瑞典查尔姆斯理工大学 博士后
● 2015-2018 瑞典哥德堡大学 研究员
● 2019-2021 中央民族大学 教授、课题组长、博士生导师
● 2021- 北京大学药学院 研究员、课题组长、博士生导师
研究方向
● 微纳电化学传感策略和药物分析应用
● 神经化学信号转导的分析与生理药理调控
● 生物分析策略与药物开发
● 神经系统疾病分子机制、药物新靶点发现及药物干预机制研究
代表性论文
1. Yuhang Jiang§, Luyao Liu§, Meiping Xiong§, Weiyu Liu, Haixin Wang, Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Chao Yuan, Lanqun Mao*, Xianchan Li*, A Single-Vesicle Electroanalytical Approach Uncovers Deficits of Vesicular Acetylcholine in Alzheimer’s Disease, J. Am. Chem. Soc. 2026, 148, 15, 15848-15858.
2. Jinger Chen§, Yuying Liu§, Lijiao Cao, Junlan Zhou, Xiaoke Nan, Chuqi Li, Weiyu Liu, Meiping Xiong, Yuhang Jiang, Qianhe Dai, Chao Yuan, Xianchan Li*, Investigating the Effect of Oxaliplatin on Vesicular Dopamine Cargo and Release Dynamics in Brain with Single-Vesicle Electrochemistry, Anal. Chem. 2026, 98, 3307-3315.
3. Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Jinchang Du, Yifei Xue, Xianchan Li*, Lanqun Mao, Single-Vesicle Electrochemistry in Fresh Brain Slices Enables In Situ Quantification of Vesicular Monoamine, J. Am. Chem. Soc. 2025, 147, 149-160.
4. Lijiao Cao, Jing Zhang, Mo Li, Junlan Zhou, Yuying Liu, Chunlan Liu*, Xianchan Li*, Single-Vesicle Electrochemistry Reveals Polysaccharide from Glochidion eriocarpum Champ. Regulates Vesicular Storage and Exocytotic Release of Dopamine. Anal. Chem. 2024, 96, 15248-15256.
5. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117.
6. Qingwei Yue†, Xianchan Li†, Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes. Angew. Chem. Int. Ed. 2020, 59, 11061– 11065.
7. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. Nanopore Opening at Flat and Nanotip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018, 12, 3010-3019.
8. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.
9. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measuring synaptic vesicles using cellular electrochemistry and nanoscale molecular imaging. Nat. Rev. Chem. 2017, 1, 0048. DOI: 10.1038/s41570-017-0048
10. Xianchan Li†, Johan Dunevall†, Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.
11. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044.
12. Xianchan Li†, Soodabeh Majdi†, Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.
本课题组常年招收硕士和博士研究生，并面向全球诚聘博士后研究人员和研究助理，有意者请将个人简历发至xcli@pku.edu.cn
