李鲜婵

研究员  课题组长  博士生导师

国家海外高层次人才计划“青年项目”获得者(2019)

电话：010-82805716;   E-mail: xcli@hsc.pku.edu.cn

地址：北京市海淀区学院路38号北京大学医学部药学楼

 

个人简历

● 2000-2004   北京大学药学院            学士

● 2004-2009  中国科学院化学研究所   博士

● 2009-2013  中国科学院化学研究所   助理研究员

● 2013-2015  瑞典查尔姆斯理工大学   博士后

● 2015-2018  瑞典哥德堡大学             研究员

● 2019-2021   中央民族大学                教授、课题组长、博士生导师

● 2021-          北京大学药学院             研究员、课题组长、博士生导师

 

研究方向

● 微纳电化学传感策略和药物分析应用

● 神经化学信号转导的分析与生理药理调控

● 生物分析策略与药物开发

● 神经系统疾病分子机制、药物新靶点发现及药物干预机制研究

 

代表性论文

1. Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117. DOI: 10.1002/anie.202117596.

2. Mengying Wang, Yuying Liu, Jinchang Du, Junlan Zhou, Lijiao Cao, Xianchan Li*，Cisplatin Inhibits Neurotransmitter Release during Exocytosis from Single Chromaffin Cells Monitored with Single Cell Amperometry. Electroanalysis, 2021. DOI: 10.1002/elan.202100398 (Invited)

3. Yuying Liu,^† Jinchang Du,^† Mengying Wang, Jing Zhang, Chunlan Liu* and Xianchan Li*, Recent Progress in Quantitatively Monitoring Vesicular Neurotransmitter Release and Storage with Micro/Nanoelectrodes. Front. Chem. 2021, 8, 591311. (Invited)

4. Qingwei Yue,^† Xianchan Li,^† Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes, Angew. Chem. Int. Ed. 2020, 59, 11061– 11065. (Co-first authors)

5. Dalei Wang,^† Xianchan Li,^† Ying Jiang, Yanan Jiang, Wenjie Ma, Ping Yu, and Lanqun Mao*. Ischemic Postconditioning Recovers Cortex Ascorbic Acid during Ischemia/Reperfusion Monitored with an Online Electrochemical System. ACS Chem. Neurosci. 2019, 10, 2576-2583. (Co-first authors)

6. Tongfang Xiao,^† Xianchan Li,^† Huan Wei, Wenliang Ji, Qingwei Yue, Ping Yu, Lanqun Mao^*In Vivo Monitoring of Oxygen Fluctuation Simultaneously at Multiple Sites of Rat Cortex during Spreading Depression. Anal. Chem. 2018, 90, 13783-13789. (Co-first authors)

7. Amir S Mohammadi,^† Xianchan Li^†, Andrew G. Ewing*. Mass Spectrometry Imaging Suggests That Cisplatin Affects Exocytotic Release by Alteration of Cell Membrane Lipids. Anal. Chem. 2018, 90, 8509-8516. (Co-first authors)

8. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. On the Nanopore Opening at Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018,12, 3010-3019.

9. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416−9423.

10. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measurement of synaptic vesicles: from the chemical content to structure and activity using cellular electrochemistry and nanoscale molecular imaging. Nature Reviews Chemistry, 2017, 1, 0048.

11. Xianchan Li,^† Johan Dunevall,^† Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.

12. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. Cover：Angew. Chem. Int. Ed. 2016, 55, 9098.

13. Xianchan Li,^† Soodabeh Majdi,^† Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.

14. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal.Chem. 2012, 84, 9416-9421.

15. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal.Chem. 2012, 84, 5285-5291.

16. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.

本课题组常年招收硕士和博士研究生，并面向全球诚聘博士后研究人员和研究助理，有意者请将个人简历发至xcli@hsc.pku.edu.cn