张力勤
研究员 课题组长 博士生导师
电话：+86-010-82805508;
E-mail: lqzhang@hsc.pku.edu.cn
地址：北京市海淀区学院路38号北京大学医学部医学科技楼北楼1503A
课题组网页：www.liqinzhanglab.com
个人简历
● 2005-2011 北京大学药学院 六年制本硕
● 2011-2016 美国佛罗里达大学化学系/医学院癌症中心 博士
● 2018-2019 美国斯坦福大学医学院 博士后
● 2020-2021 美国赛默飞世尔科技公司 高级科学家
● 2021- 北京大学药学院 特聘研究员、课题组长、博士生导师
研究方向
● 多元功能核酸探针构建和药物分析应用
● 生物分析策略与生理药理机理调控
● 功能核酸药物设计与开发
● 药物新靶点发现和药物开发
代表论文专著
1. Weihong Tan, Zilong Zhao, Liqin Zhang. Aptamer Properties, Functions, and Applications. In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications. Lihe Zhang, Xinjing Tang, Zhen Xi, Jyoti Chattopadhyaya, Eds.; John Wiley & Sons, Inc., 2022, pp 443-482.
2. Liqin Zhang, Sai Wang, Zunyi Yang, Shuichi Hoshika, Sitao Xie, Jin Li, Xigao Chen, Shuo Wan, Long Li, Steven A Benner, Weihong Tan. An Aptamer‐Nanotrain Assembled from 6‐Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells, Angewandte Chemie International Edition, 2020, 132 (2), 673-678.
3. Jun Li, Yao-Yao Fan, Man Wang, Hui-Ling Duan, Jing Zhang, Fuquan Dang, Liqin Zhang*, Zhi-Qi Zhang*. A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-Ι RNA-Binding Small Molecules. Analytical Chemistry, 2020, 92(19), 13532-13538.
4. Lianhui Zhao, Xiaoyan Qi, Xiaochen Yan, Yunfei Huang, Xingguo Liang, Liqin Zhang*, Sai Wang*, Weihong Tan*. Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation. Journal of the American Chemical Society, 2019, 141 (44), 17493-17497. (*co-corresponding authored)
5. Liqin Zhang, Shuo Wan, Ying Jiang, Yanyue Wang, Ting Fu, Qiaoling Liu, Zhijuan Cao, Liping Qiu, and Weihong Tan. Molecular Elucidation of Disease Biomarkers at the Interface of Chemistry and Biology. Journal of the American Chemical Society, 2017, 139 (7), 2532–2540.
6. Shuo Wan#, Liqin Zhang#, Sai Wang, Sena Cansiz, Hui Zhang, Yuan Liu, Cheng Cui, Weihong Tan, DNA Nanoassembly on Exosome Membrane Surfaces for Enhanced Fluorescent Detection. Journal of the American Chemical Society, 2017, 139 (15), 5289-5292. (#co-fist authored)
7. Sai Wang#, Liqin Zhang#, Shuo Wan, Sena Cansiz, Yuan Liu, Ren Cai, Cheng-Yi Hong, I-Ting Teng, Muling Shi, Yuan Wu, Yiyang Dong, and Weihong Tan, Aptasensor with Expanded Nucleotide using DNA Nanotetrahedra for Electrochemical Detection of Cancerous Exosomes. ACS Nano, 2017, 11 (4), 3943-394911. (#co-fist authored)
8. Liqin Zhang, Zunyi Yang,Thu Le Trinh, I-Ting Teng, Sai Wang, Kevin M Bradley, Shuichi Hoshika, Qunfeng Wu, Sena Cansiz, Diane J Rowold, Christopher McLendon, Myong-Sang Kim, Yuan Wu, Cheng Cui, Yuan Liu, Weijia Hou, Kimberly Stewart, Shuo Wan, Chen Liu, Steven A. Benner, Weihong Tan. Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution Give Aptamers against Glypican-3-Overexpressing Tumor Cells. Angewandte Chemie International Edition, 2016, 55(40), 12372-12375.
9. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Elizabeth Jimenez, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L Gerloff, Zhen Huang, Weihong Tan, Steven A Benner. Evolution of Functional Six-Nucleotide DNA. Journal of the American Chemical Society, 2015, 111 (4), 1449-1454.
10. Liqin Zhang, Guizhi Zhu, Lei Mei, Cuichen Wu, Liping Qiu, Cheng Cui, Yuan Liu, I-Ting Teng, and Weihong Tan. Self-Assembled DNA Immuno-Nanoflowers as Multivalent CpG Nanoagents. ACS Applied Materials & Interfaces, 2015, 7 (43), 24069-24074.
11. Liqin Zhang. Unnatural Nucleic Acids for Aptamer Selection. In Aptamers Selected by Cell-SELEX for Theranostics. Xiaohong Fang, Weihong Tan, Eds.; Springer Berlin Heidelberg, 2015, pp 35-65.
12. Sena Cansiz*, Liqin Zhang*, Cuichen Wu, Yuan Wu, I-Ting Teng, Weijia Hou, Yanyue Wang, Shuo Wan, Ren Cai, Chen Jin, Qiaoling Liu, Weihong Tan. DNA Aptamer Based Nanodrugs: Molecular Engineering for Efficiency. Chemistry–An Asian Journal, 2015, 10, 2084-2094. (*co-fist authored)
13. Li-Qin Zhang, Xiu-Wei Yang, You-Bo Zhang, Ya-Ya Zhai, Wei Xu, Bo Zhao, Dai-Lin Liu, Hong-Jian Yu. Biotransformation of Phlorizin by Human Intestinal Flora and Inhibition of Biotransformation Products on Tyrosinase Activity. Food Chemistry, 2012, 132(2), 936–942.
14. Li-Qin Zhang, Ying-Dong Huang, Xiu-Wei Yang. Intestinal Permeability of Liquiritin and Isoliquiritin in the Caco-2 cell Monolayer Model. Journal of Chinese Pharmaceutical Sciences, 2010, 19(6), 451-458.
本课题组常年招收硕士和博士研究生，并面向全球诚聘博士后研究人员和研究助理，有意者请将个人简历发至lqzhang@hsc.pku.edu.cn
