张力勤
研究员 课题组长 博士生导师
电话：+86-010-82805508;E-mail: lqzhang@hsc.pku.edu.cn
地址：北京市海淀区学院路38号北京大学医学部医学科技楼北楼1503A
个人简历
● 2005-2011 北京大学药学院 六年制本硕
● 2011-2016 美国佛罗里达大学化学系/医学院癌症中心 博士
● 2018-2019 美国斯坦福大学医学院 博士后
● 2020-2021 美国赛默飞世尔科技公司 高级科学家
● 2021- 北京大学药学院 特聘研究员、课题组长、博士生导师
研究方向
● 多元功能核酸探针构建和药物分析应用
● 生物分析策略与生理药理机理调控
● 功能核酸药物设计与开发
● 药物新靶点发现和药物开发
代表论文专著
1. Xuan Cheng#, Panzhu Yao#, Chongyu Jin, Jinchen Long, Xueling Yan, Xuyang Zhao, Tongxuan Wei, Qinguo Liu, Huang Su, Hong Xuan, Siqi Bian, Jun Li, Wenlang Liu, Zheng Zheng, Liqin Zhang*. Systematic funcitonal screening of switchable aptamer beacon probes. Nature Biomedical Engineering, 2026, 10, 980–995. doi.org/10.1038/s41551-025-01503-8
2. Haiyan Cao#, Da Xu#*, Yuming Su#, Chenshuo Zhang, Siqi Bian, Xueling Yan, Shaojin Li, Hong Xuan, Jinchen Long, Panzhu Yao, Xiyang Liu, Xuan Cheng, Huang Su, Yifan Chen, Yike Li, Jun Li, Wanlu Shi, Baocai Xing*, Kun Wang*, Liqin Zhang*. Evolution of Aptamer Materials Maps Exosomal Surface Proteins at the Nano–Bio Interface. Nano Letters, 2026, 26, 13, 4449–4461. doi.org/10.1021/acs.nanolett.6c00387
3. Huang Su#, Yifan Chen#, Xuyang Zhao#, Zengyi Lu, Tongxuan Wei, Qinguo Liu, Xiyang Liu, Qinhao Zhang, Siqi Bian, Da Xu, Liqin Zhang*. Systematic evolution of functional oligonucleotides for targeted protein degradation. Chem, 2025, 11, 5, 102408. doi.org/10.1016/j.chempr.2024.102408
4. Sharpkate Shaker#, Jun Li#, Shuo Wan#, *, Hong Xuan, Jinchen Long, Haiyan Cao, Tongxuan Wei, Qinguo Liu, Da Xu*, Steven A Benner*, Liqin Zhang*. Cancer cell target discovery: comparing laboratory evolution of expanded DNA six-nucleotide alphabets with standard four-nucleotide alphabets. Nucleic Acids Research, 2025, 53, gkaf072. doi.org/10.1093/nar/gkaf072
5. Tongxuan Wei#, Qinguo Liu#, Jun Li#, Song Song, Liqin Zhang*. Functional Aptamers In Vitro Evolution for Protein−Protein Interaction Blockage. Analytical Chemistry, 2025, 97, 8, 4341-4349. doi.org/10.1021/acs.analchem.4c04609
6. Hong Xuan#, Siqi Bian#, Qinguo Liu, Jun Li, Shaojin Li, Sharpkate Shaker, Haiyan Cao, Tongxuan Wei, Panzhu Yao, Yifan Chen, Xiyang Liu, Ruidong Xue, Youbo Zhang*, Liqin Zhang*. Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope, Acta Pharmaceutica Sinica B, 2025, 15, 3196-3209. doi.org/10.1016/j.apsb.2025.03.003
7. Yingxian Cui#, Yifan Chen#, Youbo Zhang*, Liqin Zhang*. Advances in aptamer technology for target-based drug discovery. Journal of Pharmaceutical Analysis, 2025, online, doi.org/10.1016/j.jpha.2025.101369 (Invited Review)
8. Liqin Zhang*,#, Yike Li#, Jiashu Sun#, Yongxi Zhao#, Fan Xia#, Fujian Huang#, Yuan Liu#, Xiangzhao Mao#, Sai Wang#, Xiaolei Zuo#, Da Han#, Feng Li#, Zhi Zhu#, Liping Qiu#, Xing Li#, Xiaoqiu Wu#, Yifan Chen, Xiyuan Yu, Shuangqin Li, Wen Zhu, Fan Li, Jianing Hou, Qianfan Yang, Xinghong Wu, Chao Liu, Guihua Zhang, Zhaoyang Wang, Wenjin Wan, Chaoyong Yang*, Xiaobing Zhang*, Huanghao Yang*, Xiaohong Fang*, Weihong Tan*. Aptamers in Bioanalytical Chemistry: Current Trends in Development and Application. Science China Chemistry, 2025, 68, 5357–5428. doi.org/10.1007/s11426-025-2968-x (Invited Review)
9. Xuan Cheng, Jinchen Long, Wenlong Chen, Chenshuo Zhang, Yike Li*, Liqin Zhang*. Applications of Aptamers in Pharmaceutical Analysis: Comprehensively Empowering Drug Development. Journal of Pharmaceutical and Biomedical Analysis, 2025, 268, 117179, doi.org/10.1016/j.jpba.2025.117179 (Invited Review)
10. Shaojin Li#, Youbo Zhang#,*, Xiyang Liu, Huang Su, Haiyan Cao, Hong Xuan, Yingxian Cui, Zengyi Lu, Qinhao Zhang, Yike Li, Xiaoyan Liu, Xiaoai Bao, Hailong Xu, Yanlin Wang, Xinjie Zhuo, Xinyue Zhang, Qingying Zhang*, Liqin Zhang*. Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo. Pharmacological Research, 2025, 222, 108033. doi.org/10.1016/j.phrs.2025.108033
11. Yike Li, Ziwei Han, Ludan Zhang, Ya Zhao, Yan Li, Shaokun Dong, Liqin Zhang, Chao Yuan, Yuguang Wang, Chao Liu, Jiashu Sun. Multiphase flow-enabled microfluidic sorting reveals cellular chain length-dependent pathogenic heterogeneity. Nano Today, 2025, 64, 102802. doi.org/10.1016/j.nantod.2025.102802
12. Siqi Bian, Qianwei Qiu, Chenshuo Zhang, Haiyan Cao, Hong Xuan, Xueling Yan, Jun Li, Wenlong Chen, Xiyang Liu, Yifan Chen, Jinchen Long, Huang Su, Jing Wang* and Liqin Zhang*. Evolution of Cross-Liking Aptamers for Long-Lasting Membrane Protein Labeling, Journal of the American Chemical Society, 2025, 147, 51, 46780–46786. doi/full/10.1021/jacs.5c16570
13. Yike Li, Shaohua Zhang*, Chao Liu, Jinqi Deng, Fei, Tian, Qiang Feng, Lili Qin, Lixiao Bai, Ting Fu,Liqin Zhang*, Yuguang Wang* and Jiashu Sun*. Thermophoretic Glycan Profiling of Extracellular Vesicles for Triple-negative Breast Cancer Management, Nature Communications, 2024, 15, 2292. doi.org/10.1038/s41467-024-46557-5
14. Jun Li, Panzhu Yao, Ke Tang, Xuyang Zhao, Xiyang Liu, Qinguo Liu, Tongxuan Wei, Hong Xuan, Siqi Bian, Ying Guo*, Zhenjun Yang*, Zhi-Qi Zhang*, andLiqin Zhang*. Functional Aptamers in vitro Evolution for intranuclear blockage of RNA-protein Interaction, Journal of the American Chemical Society, 2024, 146, 35, 24654-24662. doi.org/10.1021/jacs.4c08824
本课题组常年招收硕士和博士研究生，并面向全球诚聘博士后研究人员和研究助理，有意者请将个人简历发至lqzhang@hsc.pku.edu.cn
