乔雪，研究员，博士生导师。

办公电话：010-82801516

电子邮箱：qiaoxue@bjmu.edu.cn

课题组主页 http://sklnbd.bjmu.edu.cn/k/e/action/ListInfo/?classid=41

个人简历

1985年7月出生于北京

2009/09–2012/07，北京大学，药学院天然药物学系，博士。

2003/09–2009/07，北京大学，药学院（六年制），学士、硕士。

2012/08-2018/07，北京大学，药学院天然药物学系，讲师。

2016/10-2018/04，英国John Innes Centre，访问学者/博士后。

2018/08-现在，北京大学，药学院天然药物学系，副教授。

研究领域

1. 中药药效成分的生物合成。

包括中药活性成分的生物合成途径解析；生物合成酶的发现、改造及催化机制；生物催化反应等。

2. 中药化学成分及体内代谢分析新方法。

通过中药化学成分分析、质量控制、体内代谢、代谢组学等，发现中药的药效成分。

科研项目

1. 国家自然科学基金优秀青年科学基金，2022/1-2024/12，主持。

2. 国家自然科学基金面上项目，2022/1-2025/12，主持。

3. 国家自然科学基金面上项目，2020/01-2023/12，主持。

4. 北京市自然科学基金杰出青年科学基金，2018/11-2021/12，主持。

5. 国家重点研发计划，2018/12-2021/12，课题负责人。

6. 中国科协青年人才托举工程，2016/01-2018/12，主持。

奖励与学术职务

2019年中药分析与标准青年科学家奖（世界中联中药分析专业委员会）。

Fitoterapia杂志副主编（2019.9-）

WJTCM杂志青年编委（2018.8-）

代表论文

1. Meng Zhang, Yang Yi, Baihan Gao, Hui-Fei Su, Yang-Oujie Bao, Xiao-Meng Shi, Hai-Dong Wang, Fu-Dong Li, Min Ye*, Xue Qiao*. Functional characterization and protein engineering of a triterpene 3-/6-/2′-O-glycosyltransferase reveal a conserved residue critical for the regiospecificity. Angew. Chem. Int. Ed. 2022, 61(8), e202113587.

2. Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn*, Xue Qiao*. Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function. J. Adv. Res. 2022, doi.org/10.1016/j.jare.2022.03.014.

3. Kuan Chen, Meng Zhang, Min Ye*, Xue Qiao*. Site-directed mutagenesis and substrate compatibility to reveal the structure-function relationships of plant oxidosqualene cyclases. Nat. Prod. Rep. 2021, 38, 2261-2275.

4. Huifei Su, Sharpkate Shaker, Yi Kuang, Meng Zhang, Min Ye*, Xue Qiao*. Phytochemistry and cardiovascular protective effects of Huang-Qi (Astragali Radix). Med. Res. Rev. 2021, 41, 1999–2038.

5. Zhanpeng Shang, Lulu Xu, Yi Kuang, Yan Lin, Shuang Liu, Long Sun, Tao Bo, Min Ye*, Xue Qiao*. Simultaneous determination of 35 constituents and elucidation of effective constituents in a multi-herb Chinese medicine formula Xiaoer-Feire-Kechuan. J. Pharm. Anal. 2021, 11, 717-725. (Cover)

6. Zi-Long Wang#, Hao-Meng Gao#, Shuang Wang, Meng Zhang, Kuan Chen, Ya-Qun Zhang, Hai-Dong Wang, Bo-Yun Han, Lu-Lu Xu, Tian-Qiao Song, Cai-Hong Yun, Xue Qiao*, Min Ye*. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc. Natl. Acad. Sci. U. S. A. 2020, 117(48), 30816-30823

7. Meng Zhang#, Fu-Dong Li#, Kai Li#, Zi-Long Wang, Yu-Xi Wang, Jun-Bin He, Hui-Fei Su, Zhong-Yi Zhang, Chang-Biao Chi, Xiao-Meng Shi, Cai-Hong Yun, Zhi-Yong Zhang, Zhen-Ming Liu, Liang-Ren Zhang, Dong-Hui Yang, Ming Ma*, Xue Qiao*, Min Ye*. Functional characterization and structural basis of an efficient di-C-glycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc. 2020, 142, 3506-3512.

8. Kuan Chen, Zhimin Hu, Wei Song, Zi-long Wang, Jun-bin He, Xiao-meng Shi, Qing-hua Cui, Xue Qiao*, Min Ye*. Diversity of O-glycosyltransferases contributes to the biosynthesis of flavonoid and triterpenoid glycosides in Glycyrrhiza uralensis. ACS Synth. Biol. 2019, 8, 1858−1866.

9. Jun-Bin He#, Peng Zhao#, Zhi-Min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-Hong Yun*, Xue Qiao*, Min Ye*. Molecular characterization and structural basis of a promiscuous C-glycosyltransferase from Trollius chinensis. Angew. Chem. Int. Ed. 2019, 58, 11513-11520.

10. Xue Qiao#, Qi Wang#, Shuang Wang, Yi Kuang, Kai Li, Wei Song, Min Ye*. A 42-markers pharmacokinetic study reveals interactions of berberine and glycyrrhizic acid in the anti-diabetic Chinese medicine formula Gegen-Qinlian Decoction. Front. Pharmacol. 2018, 9, 622.

11. Wei Song#, Xue Qiao#, Kuan Chen, Ying Wang, Shuai Ji, Jin Feng, Kai Li, Yan Lin, Min Ye*. Biosynthesis-based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids. Anal. Chem. 2017, 89(5), 3146-3153.

12. Xue Qiao, Xiong-hao Lin, Shuai Ji, Zheng-xiang Zhang, Tao Bo, De-an Guo, Min Ye*. Global profiling and novel structure discovery using multiple neutral loss/precursor ion scanning combined with substructure recognition and statistical analysis (MNPSS): Characterization of terpene-conjugated curcuminoids in Curcuma longa as a case study. Anal. Chem. 2016, 88(1), 703-710.

本课题组常年招收硕士和博士研究生，并面向全球诚聘博士后研究人员和研究助理，有意者请将个人简历发至qiaoxue@bjmu.edu.cn